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Bifidobacterium bifidum PRL2010 modulates the host innate immune response.

ABSTRACT: Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-?B activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.

SUBMITTER: Turroni F

PROVIDER: S-EPMC3911076 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Bifidobacterium bifidum PRL2010 modulates the host innate immune response.

Turroni Francesca F Taverniti Valentina V Ruas-Madiedo Patricia P Duranti Sabrina S Guglielmetti Simone S Lugli Gabriele Andrea GA Gioiosa Laura L Palanza Paola P Margolles Abelardo A van Sinderen Douwe D Ventura Marco M

Applied and environmental microbiology 20131115 2

Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines ...[more]

PMID: 24242237

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