Ontology highlight
ABSTRACT:
SUBMITTER: Sakamoto T
PROVIDER: S-EPMC3911284 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Sakamoto Takeharu T Weng Jane S JS Hara Toshiro T Yoshino Seiko S Kozuka-Hata Hiroko H Oyama Masaaki M Seiki Motoharu M
Molecular and cellular biology 20131028 1
Hypoxia-inducible factor 1 (HIF-1) plays a key role in the cellular adaptation to hypoxia. Although HIF-1 is usually strongly suppressed by posttranslational mechanisms during normoxia, HIF-1 is active and enhances tumorigenicity in malignant tumor cells that express the membrane protease MT1-MMP. The cytoplasmic tail of MT1-MMP, which can bind a HIF-1 suppressor protein called factor inhibiting HIF-1 (FIH-1), promotes inhibition of FIH-1 by Mint3 during normoxia. To explore possible links betwe ...[more]