Ontology highlight
ABSTRACT:
SUBMITTER: Luo Q
PROVIDER: S-EPMC3911403 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Luo Qingwei Q Kumar Pardeep P Vickers Tim J TJ Sheikh Alaullah A Lewis Warren G WG Rasko David A DA Sistrunk Jeticia J Fleckenstein James M JM
Infection and immunity 20131118 2
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of death due to diarrheal illness among young children in developing countries, and there is currently no effective vaccine. Many elements of ETEC pathogenesis are still poorly defined. Here we demonstrate that YghJ, a secreted ETEC antigen identified in immunoproteomic studies using convalescent patient sera, is required for efficient access to small intestinal enterocytes and for the optimal delivery of heat-labile toxin (LT). Furtherm ...[more]