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The rigid amphipathic fusion inhibitor dUY11 acts through photosensitization of viruses.

ABSTRACT: Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen ((1)O(2)), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.

SUBMITTER: Vigant F

PROVIDER: S-EPMC3911596 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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The rigid amphipathic fusion inhibitor dUY11 acts through photosensitization of viruses.

Vigant Frederic F Hollmann Axel A Lee Jihye J Santos Nuno C NC Jung Michael E ME Lee Benhur B

Journal of virology 20131127 3

Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen ((1)O(2)), similar to the mechanistic paradigm established for LJ001, a chemically unrelated ...[more]

PMID: 24284320

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