Ontology highlight
ABSTRACT:
SUBMITTER: Vigant F
PROVIDER: S-EPMC3911596 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Vigant Frederic F Hollmann Axel A Lee Jihye J Santos Nuno C NC Jung Michael E ME Lee Benhur B
Journal of virology 20131127 3
Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen ((1)O(2)), similar to the mechanistic paradigm established for LJ001, a chemically unrelated ...[more]