Expression profile of microRNAs in Epstein-Barr virus-infected AGS gastric carcinoma cells.
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ABSTRACT:
SUBMITTER: Marquitz AR
PROVIDER: S-EPMC3911632 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Expression profile of microRNAs in Epstein-Barr virus-infected AGS gastric carcinoma cells.
Marquitz Aron R AR Mathur Anuja A Chugh Pauline E PE Dittmer Dirk P DP Raab-Traub Nancy N
Journal of virology 20131113 2
Latent infection with Epstein-Barr virus (EBV) is responsible for multiple types of malignancies, including 10% of all gastric carcinomas. The microRNA (miRNA) expression in several EBV-infected AGS gastric carcinoma cell lines was determined. Infected cells expressed the viral BamHI A rightward transcript (BART) miRNAs at high levels and had consistently decreased expression of a small fraction of cellular miRNAs with specific downregulation of tumor suppressor miRNAs. These changes likely refl ...[more]
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