Expression profile of microRNAs in Epstein-Barr virus-infected AGS gastric carcinoma cells.

ABSTRACT: Latent infection with Epstein-Barr virus (EBV) is responsible for multiple types of malignancies, including 10% of all gastric carcinomas. The microRNA (miRNA) expression in several EBV-infected AGS gastric carcinoma cell lines was determined. Infected cells expressed the viral BamHI A rightward transcript (BART) miRNAs at high levels and had consistently decreased expression of a small fraction of cellular miRNAs with specific downregulation of tumor suppressor miRNAs. These changes likely reflect expression of the viral noncoding RNAs and not latent protein expression.

SUBMITTER: Marquitz AR 

PROVIDER: S-EPMC3911632 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature