Ontology highlight
ABSTRACT:
SUBMITTER: Guendel I
PROVIDER: S-EPMC3911635 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Guendel Irene I Iordanskiy Sergey S Van Duyne Rachel R Kehn-Hall Kylene K Saifuddin Mohammed M Das Ravi R Jaworski Elizabeth E Sampey Gavin C GC Senina Svetlana S Shultz Leonard L Narayanan Aarthi A Chen Hao H Lepene Benjamin B Zeng Chen C Kashanchi Fatah F
Journal of virology 20131113 2
The implementation of new antiretroviral therapies targeting transcription of early viral proteins in postintegrated HIV-1 can aid in overcoming current therapy limitations. Using high-throughput screening assays, we have previously described a novel Tat-dependent HIV-1 transcriptional inhibitor named 6-bromoindirubin-3'-oxime (6BIO). The screening of 6BIO derivatives yielded unique compounds that show potent inhibition of HIV-1 transcription. We have identified a second-generation derivative ca ...[more]