Ontology highlight
ABSTRACT:
SUBMITTER: Boswell KL
PROVIDER: S-EPMC3911819 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Boswell Kristin L KL Paris Robert R Boritz Eli E Ambrozak David D Yamamoto Takuya T Darko Sam S Wloka Kaska K Wheatley Adam A Narpala Sandeep S McDermott Adrian A Roederer Mario M Haubrich Richard R Connors Mark M Ake Julie J Douek Daniel C DC Kim Jerome J Petrovas Constantinos C Koup Richard A RA
PLoS pathogens 20140130 1
The interaction between follicular T helper cells (TFH) and B cells in the lymph nodes and spleen has a major impact on the development of antigen-specific B cell responses during infection or vaccination. Recent studies described a functional equivalent of these cells among circulating CD4 T cells, referred to as peripheral TFH cells. Here, we characterize the phenotype and in vitro B cell helper activity of peripheral TFH populations, as well as the effect of HIV infection on these populations ...[more]