Unknown

Dataset Information

0

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

ABSTRACT: N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human methyltransferase-like 14 (METTL14) catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-METTL14 that functions in cellular m(6)A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.

SUBMITTER: Liu J 

PROVIDER: S-EPMC3911877 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Liu Jianzhao J   Yue Yanan Y   Han Dali D   Wang Xiao X   Fu Ye Y   Zhang Liang L   Jia Guifang G   Yu Miao M   Lu Zhike Z   Deng Xin X   Dai Qing Q   Chen Weizhong W   He Chuan C  

Nature chemical biology 20131206 2

N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human methyltransferase-like 14 (METTL14) catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-METTL14 that functions in cellular m(6)A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with t  ...[more]

Similar Datasets

Unknown Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.
| S-EPMC5630681 | biostudies-other
Transcriptomics Identification and Characterization of the Mammalian Nuclear RNA N6-Adenosine Methyltransferase Core Complex
2013-11-29 | E-GEOD-46705 | biostudies-arrayexpress
Unknown Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer.
| S-EPMC7446161 | biostudies-literature
Transcriptomics Identification and Characterization of the Mammalian Nuclear RNA N6-Adenosine Methyltransferase Core Complex
2013-11-29 | GSE46705 | GEO
Unknown N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.
| S-EPMC6463480 | biostudies-literature
Unknown Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.
| S-EPMC8599731 | biostudies-literature
Unknown METTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.
| S-EPMC7896299 | biostudies-literature
Unknown N6-adenosine methylation in MiRNAs.
| S-EPMC4344304 | biostudies-literature
Unknown N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance.
| S-EPMC7176415 | biostudies-literature
Unknown Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication.
| S-EPMC5533915 | biostudies-literature