Ontology highlight
ABSTRACT: From the clinical editor
The authors of this study demonstrate superior treatment properties of resistant leukemia cell lines by utilizing nanodiamond vectors loaded with daunorubicin, paving the way to clinical studies in the hopefully not too distant future.
SUBMITTER: Man HB
PROVIDER: S-EPMC3912225 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Man Han B HB Kim Hansung H Kim Ho-Joong HJ Robinson Erik E Liu Wing Kam WK Chow Edward Kai-Hua EK Ho Dean D
Nanomedicine : nanotechnology, biology, and medicine 20130803 2
Nanodiamonds (NDs) are promising candidates in nanomedicine, demonstrating significant potential as gene/drug delivery platforms for cancer therapy. We have synthesized ND vectors capable of chemotherapeutic loading and delivery with applications towards chemoresistant leukemia. The loading of Daunorubicin (DNR) onto NDs was optimized by adjusting reaction parameters such as acidity and concentration. The resulting conjugate, a novel therapeutic payload for NDs, was characterized extensively for ...[more]