Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3912312 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wang Xiaoshu X Fan Xiang X Yu Zhanyang Z Liao Zhengbu Z Zhao Jianhua J Mandeville Emiri E Guo Shuzhen S Lo Eng H EH Wang Xiaoying X
Stroke 20131224 2
<h4>Background and purpose</h4>Tissue-type plasminogen activator (tPA) in combination with recombinant annexin A2 (rA2) is known to reduce acute brain damage after focal ischemia. Here, we ask whether tPA-plus-rA2 combination therapy can lead to sustained long-term neurological improvements as well.<h4>Methods</h4>We compared the effects of intravenous high-dose tPA alone (10 mg/kg) versus a combination of low-dose tPA (5 mg/kg) plus 10 mg/kg rA2 in a model of focal embolic cerebral ischemia in ...[more]