Ontology highlight
ABSTRACT:
SUBMITTER: Akagi K
PROVIDER: S-EPMC3912410 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Akagi Keiko K Li Jingfeng J Broutian Tatevik R TR Padilla-Nash Hesed H Xiao Weihong W Jiang Bo B Rocco James W JW Teknos Theodoros N TN Kumar Bhavna B Wangsa Danny D He Dandan D Ried Thomas T Symer David E DE Gillison Maura L ML
Genome research 20131107 2
Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of "looping" by which HPV ...[more]