Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses.
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ABSTRACT:
SUBMITTER: Borgwardt DS
PROVIDER: S-EPMC3912440 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
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Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses.
Borgwardt Derek S DS Martin Aaron D AD Van Hemert Jonathan R JR Yang Jianyi J Fischer Carol L CL Recker Erica N EN Nair Prashant R PR Vidva Robinson R Chandrashekaraiah Shwetha S Progulske-Fox Ann A Drake David D Cavanaugh Joseph E JE Vali Shireen S Zhang Yang Y Brogden Kim A KA
Scientific reports 20140129
Histatins are human salivary gland peptides with anti-microbial and anti-inflammatory activities. In this study, we hypothesized that histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and attenuates HagB-induced chemokine responses in human myeloid dendritic cells. Histatin 5 bound to immobilized HagB in a surface plasmon resonance (SPR) spectroscopy-based biosensor system. SPR spectroscopy kinetic and equilibrium analyses, protein microarray studies, and I-TASSER structural mo ...[more]
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