Ontology highlight
ABSTRACT:
SUBMITTER: Chai Y
PROVIDER: S-EPMC3912452 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20131209 1
Heterocyclic diamidines are strong DNA minor-groove binders and have excellent antiparasitic activity. To extend the biological activity of these compounds, a series of arylimidamides (AIAs) analogues, which have better uptake properties in Leishmania and Trypanosoma cruizi than diamidines, was prepared. The binding of the AIAs to DNA was investigated by Tm , fluorescence displacement titration, circular dichroism, DNase I footprinting, biosensor surface plasmon resonance, X-ray crystallography ...[more]