Ontology highlight
ABSTRACT:
SUBMITTER: Kanai Y
PROVIDER: S-EPMC3912526 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Kanai Yoshimitsu Y Wang Daliang D Hirokawa Nobutaka N
The Journal of cell biology 20140127 3
Multifunctional low-density lipoprotein (LDL) receptor-related protein 1 (LRP1) recognizes and internalizes a large number of diverse ligands, including LDL and factor VIII. However, little is known about the regulation of LRP1 endocytosis. Here, we show that a microtubule-based motor protein, KIF13B, in an unexpected and unconventional function, enhances caveolin-dependent endocytosis of LRP1. KIF13B was highly expressed in the liver and was localized on the sinusoidal plasma membrane of hepato ...[more]