Ontology highlight
ABSTRACT:
SUBMITTER: Frost LS
PROVIDER: S-EPMC3912860 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Frost Laura S LS Lopes Vanda S VS Stefano Frank P FP Bragin Alvina A Williams David S DS Mitchell Claire H CH Boesze-Battaglia Kathleen K
Visual neuroscience 20130423 3
Cathepsin-D (Cat-D) is a major proteolytic enzyme in phagocytic cells. In the retinal pigment epithelium (RPE), it is responsible for the daily degradation of photoreceptor outer segments (POSs) to maintain retinal homeostasis. Melanoregulin (MREG)-mediated loss of phagocytic capacity has been linked to diminished intracellular Cat-D activity. Here, we demonstrate that loss of MREG enhances the secretion of intermediate Cat-D (48 kDa), resulting in a net enhancement of extracellular Cat-D activi ...[more]