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Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases.


ABSTRACT:

Background

Whether probiotics, which can influence the microbiome, prevent infant eczema or allergic disease remains an open question. Most studies have focused on high-risk infants.

Objectives

We sought to assess whether consumption of probiotic milk products protects against atopic eczema, rhinoconjunctivitis, and asthma in early childhood in a large population-based pregnancy cohort (the Norwegian Mother and Child Cohort study).

Methods

We examined associations between consumption of probiotic milk products in pregnancy and infancy with questionnaire-reported atopic eczema, rhinoconjunctivitis, and asthma in 40,614 children. Relative risks (RRs) were calculated by using general linear models adjusted for potential confounders.

Results

Consumption of probiotic milk in pregnancy was associated with a slightly reduced relative risk (RR) of atopic eczema at 6 months (adjusted RR, 0.94; 95% CI, 0.89-0.99) and of rhinoconjunctivitis between 18 and 36 months (adjusted RR, 0.87; 95% CI, 0.78-0.98) compared with no consumption during pregnancy. Maternal history of allergic disease did not notably influence the associations. When both the mother (during pregnancy) and infant (after 6 months of age) had consumed probiotic milk, the adjusted RR of rhinoconjunctivitis was 0.80 (95% CI, 0.68-0.93) relative to no consumption by either. Probiotic milk consumption was not associated with asthma at 36 months.

Conclusions

In this population-based cohort consumption of probiotic milk products was related to a reduced incidence of atopic eczema and rhinoconjunctivitis, but no association was seen for incidence of asthma by 36 months of age.

SUBMITTER: Bertelsen RJ 

PROVIDER: S-EPMC3912862 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases.

Bertelsen Randi J RJ   Brantsæter Anne Lise AL   Magnus Maria C MC   Haugen Margaretha M   Myhre Ronny R   Jacobsson Bo B   Longnecker Matthew P MP   Meltzer Helle M HM   London Stephanie J SJ  

The Journal of allergy and clinical immunology 20130910 1


<h4>Background</h4>Whether probiotics, which can influence the microbiome, prevent infant eczema or allergic disease remains an open question. Most studies have focused on high-risk infants.<h4>Objectives</h4>We sought to assess whether consumption of probiotic milk products protects against atopic eczema, rhinoconjunctivitis, and asthma in early childhood in a large population-based pregnancy cohort (the Norwegian Mother and Child Cohort study).<h4>Methods</h4>We examined associations between c  ...[more]

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