Ontology highlight
ABSTRACT:
SUBMITTER: Yun Y
PROVIDER: S-EPMC3913075 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Yun Yan Y Lane Simon I R SI Jones Keith T KT
Development (Cambridge, England) 20140101 1
As women get older their oocytes become susceptible to chromosome mis-segregation. This generates aneuploid embryos, leading to increased infertility and birth defects. Here we examined the provenance of aneuploidy by tracking chromosomes and their kinetochores in oocytes from young and aged mice. Changes consistent with chromosome cohesion deterioration were found with age, including increased interkinetochore distance and loss of the centromeric protector of cohesion SGO2 in metaphase II arres ...[more]