Ontology highlight
ABSTRACT:
SUBMITTER: Huber G
PROVIDER: S-EPMC3913500 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
BioMed research international 20140112
When bound to the envelope of viruses, factor H (FH), a soluble regulator of complement activation, contributes to the protection against a potent immune defense mechanism, the complement-mediated lysis (CML). Thus, removing FH from the surface renders viruses, such as HIV, susceptible to CML. For a proof of concept, we developed a construct consisting of recombinant bifunctional single-chain variable fragment (scFv) based on a monoclonal antibody against Friend murine leukemia virus (F-MuLV) en ...[more]