Ontology highlight
ABSTRACT:
SUBMITTER: Salomon A
PROVIDER: S-EPMC3913561 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Salomon Aidy A Krachmarov Chavdar C Lai Zhong Z Honnen William W Zingman Barry S BS Sarlo Julie J Gorny Miroslaw K MK Zolla-Pazner Susan S Robinson James E JE Pinter Abraham A
Virology 20131112
Primary HIV-1 isolates are relatively resistant to neutralization by antibodies commonly induced after infection or vaccination. This is generally attributed to masking of sensitive epitopes by the V1/V2 domain and/or glycans situated at various positions in Env. Here we identified a novel masking effect mediated by subtype C-specific V3 sequences that contributes to the V1/V2-independent and glycan-independent neutralization resistance of chimeric and primary Envs to antibodies directed against ...[more]