Xenon and other volatile anesthetics change domain structure in model lipid raft membranes.
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ABSTRACT:
SUBMITTER: Weinrich M
PROVIDER: S-EPMC3914297 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Xenon and other volatile anesthetics change domain structure in model lipid raft membranes.
Weinrich Michael M Worcester David L DL
The journal of physical chemistry. B 20131206 50
Inhalation anesthetics have been in clinical use for over 160 years, but the molecular mechanisms of action continue to be investigated. Direct interactions with ion channels received much attention after it was found that anesthetics do not change the structure of homogeneous model membranes. However, it was recently found that halothane, a prototypical anesthetic, changes domain structure of a binary lipid membrane. The noble gas xenon is an excellent anesthetic and provides a pivotal test of ...[more]
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