Ontology highlight
ABSTRACT:
SUBMITTER: Steffan JJ
PROVIDER: S-EPMC3914878 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Steffan Joshua J JJ Dykes Samantha S SS Coleman David T DT Adams Lisa K LK Rogers Donna D Carroll Jennifer L JL Williams B Jill BJ Cardelli James A JA
PloS one 20140205 2
Invasion and subsequent metastasis is the major cause of death from most cancers including prostate cancer. Herein we report on the potential tumor suppressive properties of Rab7, a GTPase that regulates trafficking of lysosomes. The movement of lysosomes to the cell surface in response to environmental cues increases the secretion of proteinases and cell invasion. We determined that Troglitazone and other members of the Thiazolidinedione family inhibit cell-surface directed lysosome trafficking ...[more]