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Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives.


ABSTRACT: An N-acetylhexosamine 1-kinase from Bifidobacterium infantis (NahK_15697), a guanosine 5'-diphosphate (GDP)-mannose pyrophosphorylase from Pyrococcus furiosus (PFManC), and an Escherichia coli inorganic pyrophosphatase (EcPpA) were used efficiently for a one-pot three-enzyme synthesis of GDP-mannose, GDP-glucose, their derivatives, and GDP-talose. This study represents the first facile and efficient enzymatic synthesis of GDP-sugars and derivatives starting from monosaccharides and derivatives.

SUBMITTER: Li L 

PROVIDER: S-EPMC3915774 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives.

Li Lei L   Liu Yonghui Y   Wan Yue Y   Li Yanhong Y   Chen Xi X   Zhao Wei W   Wang Peng George PG  

Organic letters 20131011 21


An N-acetylhexosamine 1-kinase from Bifidobacterium infantis (NahK_15697), a guanosine 5'-diphosphate (GDP)-mannose pyrophosphorylase from Pyrococcus furiosus (PFManC), and an Escherichia coli inorganic pyrophosphatase (EcPpA) were used efficiently for a one-pot three-enzyme synthesis of GDP-mannose, GDP-glucose, their derivatives, and GDP-talose. This study represents the first facile and efficient enzymatic synthesis of GDP-sugars and derivatives starting from monosaccharides and derivatives. ...[more]

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