Ontology highlight
ABSTRACT:
SUBMITTER: Wu D
PROVIDER: S-EPMC3915908 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wu Donghui D Muhlrad Denise D Bowler Matthew W MW Jiang Shimin S Liu Zhou Z Parker Roy R Song Haiwei H
Cell research 20131119 2
The evolutionarily conserved Lsm1-7-Pat1 complex is the most critical activator of mRNA decapping in eukaryotic cells and plays many roles in normal decay, AU-rich element-mediated decay, and miRNA silencing, yet how Pat1 interacts with the Lsm1-7 complex is unknown. Here, we show that Lsm2 and Lsm3 bridge the interaction between the C-terminus of Pat1 (Pat1C) and the Lsm1-7 complex. The Lsm2-3-Pat1C complex and the Lsm1-7-Pat1C complex stimulate decapping in vitro to a similar extent and exhibi ...[more]