Ontology highlight
ABSTRACT:
SUBMITTER: Cao Y
PROVIDER: S-EPMC3916047 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Cao Ya Y Yang Lifang L Jiang Wuzhong W Wang Xiaoyi X Liao Weihua W Tan Guolin G Liao Yuping Y Qiu Yuanzheng Y Feng Deyun D Tang Faqing F Hou Bob L BL Zhang Ling L Fu Jia J He Fengjiao F Liu Xiaoyu X Jiang Wenjuan W Yang Tubao T Sun Lun-Quan LQ
Molecular therapy : the journal of the American Society of Gene Therapy 20131028 2
The ability of the 10-23 DNAzyme to specifically cleave RNA with high efficiency has fuelled expectation that this agent may have useful applications for targeted therapy. Here, we, for the first time, investigated the antitumor and radiosensitizing effects of a DNAzyme (DZ1) targeted to the Epstein-Barr virus (EBV)-LMP1 mRNA of nasopharyngeal carcinoma (NPC) in patients. Preclinical studies indicated that the DNAzyme was safe and well tolerated. A randomized and double-blind clinical study was ...[more]