Ontology highlight
ABSTRACT:
SUBMITTER: Pitkanen E
PROVIDER: S-EPMC3916221 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Pitkänen Esa E Jouhten Paula P Hou Jian J Syed Muhammad Fahad MF Blomberg Peter P Kludas Jana J Oja Merja M Holm Liisa L Penttilä Merja M Rousu Juho J Arvas Mikko M
PLoS computational biology 20140206 2
We introduce a novel computational approach, CoReCo, for comparative metabolic reconstruction and provide genome-scale metabolic network models for 49 important fungal species. Leveraging on the exponential growth in sequenced genome availability, our method reconstructs genome-scale gapless metabolic networks simultaneously for a large number of species by integrating sequence data in a probabilistic framework. High reconstruction accuracy is demonstrated by comparisons to the well-curated Sacc ...[more]