Ontology highlight
ABSTRACT:
SUBMITTER: Boomer JS
PROVIDER: S-EPMC3916383 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Boomer Jonathan S JS Green Jonathan M JM Hotchkiss Richard S RS
Virulence 20130925 1
Sepsis remains the leading cause of death in most intensive care units. Advances in understanding the immune response to sepsis provide the opportunity to develop more effective therapies. The immune response in sepsis can be characterized by a cytokine-mediated hyper-inflammatory phase, which most patients survive, and a subsequent immune-suppressive phase. Patients fail to eradicate invading pathogens and are susceptible to opportunistic organisms in the hypo-inflammatory phase. Many mechanism ...[more]