Ontology highlight
ABSTRACT:
SUBMITTER: Jamroze A
PROVIDER: S-EPMC3916527 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Jamroze Anmbreen A Perugino Giuseppe G Valenti Anna A Rashid Naeem N Rossi Mosè M Akhtar Muhammad M Ciaramella Maria M
The Journal of biological chemistry 20131217 6
Reverse gyrase is a DNA topoisomerase specific for hyperthermophilic bacteria and archaea. It catalyzes the peculiar ATP-dependent DNA-positive supercoiling reaction and might be involved in the physiological adaptation to high growth temperature. Reverse gyrase comprises an N-terminal ATPase and a C-terminal topoisomerase domain, which cooperate in enzyme activity, but details of its mechanism of action are still not clear. We present here a functional characterization of PcalRG, a novel revers ...[more]