Dataset Information

Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

ABSTRACT: Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to ?80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.

SUBMITTER: Fagerberg L

PROVIDER: S-EPMC3916642 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

Fagerberg Linn L Hallström Björn M BM Oksvold Per P Kampf Caroline C Djureinovic Dijana D Odeberg Jacob J Habuka Masato M Tahmasebpoor Simin S Danielsson Angelika A Edlund Karolina K Asplund Anna A Sjöstedt Evelina E Lundberg Emma E Szigyarto Cristina Al-Khalili CA Skogs Marie M Takanen Jenny Ottosson JO Berling Holger H Tegel Hanna H Mulder Jan J Nilsson Peter P Schwenk Jochen M JM Lindskog Cecilia C Danielsson Frida F Mardinoglu Adil A Sivertsson Asa A von Feilitzen Kalle K Forsberg Mattias M Zwahlen Martin M Olsson IngMarie I Navani Sanjay S Huss Mikael M Nielsen Jens J Ponten Fredrik F Uhlén Mathias M

Molecular & cellular proteomics : MCP 20131205 2

Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas ...[more]

PMID: 24309898

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Dataset Information

Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

Publications

Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

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