Dataset Information
PH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T1 MRI Contrast by Her2-Targeting.
Ontology highlight
ABSTRACT:
SUBMITTER: Hong BJ
PROVIDER: S-EPMC3916701 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and <i>T</i><sub>1</sub> MRI Contrast by Her2-Targeting.
Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems 20130901 9
<b>A PCN theranostic platform</b> comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and Gd<sup>III</sup>-based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellular Gd<sup>III</sup>-uptake in comparison with clinically approved DOTA-Gd<sup>III</sup>, leading to significant <i>T</i><sub>1</sub> MRI contrast enhancem ...[more]