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PH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T1 MRI Contrast by Her2-Targeting.

ABSTRACT: A PCN theranostic platform comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and GdIII-based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellular GdIII-uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancement.

SUBMITTER: Hong BJ

PROVIDER: S-EPMC3916701 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T1 MRI Contrast by Her2-Targeting.

Hong Bong Jin BJ Swindell Elden P EP Macrenaris Keith W KW Hankins Patrick L PL Chipre Anthony J AJ Mastarone Daniel J DJ Ahn Richard W RW Meade Thomas J TJ O'Halloran Thomas V TV Nguyen Sonbinh T ST

Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems 20130901 9

A PCN theranostic platform comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and GdIII-based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellular GdIII-uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancem ...[more]

PMID: 24516291

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