Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC3916760 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Liu Suling S Cong Yang Y Wang Dong D Sun Yu Y Deng Lu L Liu Yajing Y Martin-Trevino Rachel R Shang Li L McDermott Sean P SP Landis Melissa D MD Hong Suhyung S Adams April A D'Angelo Rosemarie R Ginestier Christophe C Charafe-Jauffret Emmanuelle E Clouthier Shawn G SG Birnbaum Daniel D Wong Stephen T ST Zhan Ming M Chang Jenny C JC Wicha Max S MS
Stem cell reports 20131227 1
Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are resistant to radiation and chemotherapy, and contribute to relapse. Although several BCSC markers have been described, it is unclear whether these markers identify the same or independent BCSCs. Here, we show that BCSCs exist in distinct mesenchymal-like (epithelial-mesenchymal transition [EMT]) and epithelial-like (mesenchymal-epithelial transition [MET]) states. Mesenchymal-like BCSCs characterized as ...[more]