Ontology highlight
ABSTRACT:
SUBMITTER: Dinarvand P
PROVIDER: S-EPMC3916882 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Dinarvand Peyman P Hassanian Seyed Mahdi SM Qureshi Shabir H SH Manithody Chandrashekhara C Eissenberg Joel C JC Yang Likui L Rezaie Alireza R AR
Blood 20131119 6
The extracellular nuclear proteins, histone H4 (H4) and high mobility group box 1 (HMGB1), released by injured cells during the activation of inflammation and coagulation pathways provoke potent inflammatory responses through interaction with pathogen-related pattern recognition receptors (ie, Toll-like receptors [TLRs] and receptor for advanced glycation end products [RAGE]) present on vascular and innate immune cells. Inorganic polyphosphate (polyP) has emerged as a key modulator of coagulatio ...[more]