Dataset Information

Association of genetic variants of the ?-kinase 1 gene with myocardial infarction in community-dwelling individuals.

ABSTRACT: We previously demonstrated that rs2074380 (G?A, Gly870Ser) and rs2074381 (A?G, Asn916Asp) of the ?-kinase 1 gene (ALPK1) were significantly associated with chronic kidney disease (CKD) in individuals with diabetes mellitus. As CKD is a significant risk factor for coronary heart disease, we hypothesized that rs2074380 and rs2074381 of ALPK1 may contribute to the genetic susceptibility to myocardial infarction (MI) through affecting the susceptibility to CKD. The aim of the present study was to investigate a possible association of rs2074380 and rs2074381 with MI in community-dwelling individuals. The study subjects comprised 5,771 community-dwelling individuals (41 subjects with MI and 5,730 controls) who were recruited to a population-based cohort study in Inabe, Japan. The comparison of allele frequencies and genotype distributions using the Chi-square test revealed that rs2074380 and rs2074381 were significantly associated with MI (P<0.05). The multivariable logistic regression analysis with adjustment for covariates demonstrated that rs2074380 (P=0.0354, dominant model) and rs2074381 (P=0.0438, dominant model) were significantly associated with MI, with the minor A and G alleles, respectively, being protective against this condition. A haplotype analysis of these polymorphisms indicated that the frequency of the major haplotype, G (rs2074380)-A (rs2074381), was significantly higher (permutation P=0.012), whereas that of the minor haplotype A-G was significantly lower (P=0.020), in subjects with MI compared to that observed among controls. Therefore, ALPK1 may be a susceptible locus for MI.

SUBMITTER: Fujimaki T

PROVIDER: S-EPMC3917049 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Association of genetic variants of the α-kinase 1 gene with myocardial infarction in community-dwelling individuals.

Fujimaki Tetsuo T Horibe Hideki H Oguri Mitsutoshi M Kato Kimihiko K Yamada Yoshiji Y

Biomedical reports 20131030 1

We previously demonstrated that rs2074380 (G→A, Gly870Ser) and rs2074381 (A→G, Asn916Asp) of the α-kinase 1 gene (<i>ALPK1</i>) were significantly associated with chronic kidney disease (CKD) in individuals with diabetes mellitus. As CKD is a significant risk factor for coronary heart disease, we hypothesized that rs2074380 and rs2074381 of <i>ALPK1</i> may contribute to the genetic susceptibility to myocardial infarction (MI) through affecting the susceptibility to CKD. The aim of the present s ...[more]

PMID: 24649083

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Project description:Importance:Cardiac magnetic resonance (CMR) imaging can identify unrecognized myocardial infarction (UMI) in the general population. Unrecognized myocardial infarction by CMR portends poor prognosis in the short term but, to our knowledge, long-term outcomes are not known. Objective:To determine the long-term outcomes of UMI by CMR compared with clinically recognized myocardial infarction (RMI) and no myocardial infarction (MI). Design, Setting, and Participants:Participants of the population-based, prospectively enrolled ICELAND MI cohort study (aged 67-93 years) were characterized with CMR at baseline (from January 2004-January 2007) and followed up for up to 13.3 years. Kaplan-Meier time-to-event analyses and a Cox regression were used to assess the association of UMI at baseline with death and future cardiovascular events. Main Outcomes and Measures:The primary outcome was all-cause mortality. Secondary outcomes were a composite of major adverse cardiac events (MACE: death, nonfatal MI, and heart failure). Results:Of 935 participants, 452 (48.3%) were men; the mean (SD) age of participants with no MI, UMI, and RMI was 75.6 (5.3) years, 76.8 (5.2) years, and 76.8 (4.7) years, respectively. At 3 years, UMI and no MI mortality rates were similar (3%) and lower than RMI rates (9%). At 5 years, UMI mortality rates (13%) increased and were higher than no MI rates (8%) but still lower than RMI rates (19%). By 10 years, UMI and RMI mortality rates (49% and 51%, respectively) were not statistically different; both were significantly higher than no MI (30%) (P?<?.001). After adjusting for age, sex, and diabetes, UMI by CMR had an increased risk of death (hazard ratio [HR], 1.61; 95% CI, 1.27-2.04), MACE (HR, 1.56; 95% CI, 1.26-1.93), MI (HR, 2.09; 95% CI, 1.45-3.03), and heart failure (HR, 1.52; 95% CI, 1.09-2.14) compared with no MI and statistically nondifferent risk of death (HR, 0.99; 95% CI, 0.71-1.38) and MACE (HR, 1.23; 95% CI, 0.91-1.66) vs RMI. Conclusions and Relevance:In this study, all-cause mortality of UMI was higher than no MI, but within 10 years from baseline evaluation was equivalent with RMI. Unrecognized MI was also associated with an elevated risk of nonfatal MI and heart failure. Whether secondary prevention can alter the prognosis of UMI will require prospective testing.

Dataset Information

Association of genetic variants of the ?-kinase 1 gene with myocardial infarction in community-dwelling individuals.

Publications

Association of genetic variants of the α-kinase 1 gene with myocardial infarction in community-dwelling individuals.

Similar Datasets

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