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Marine natural products with P-glycoprotein inhibitor properties.

ABSTRACT: P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.

SUBMITTER: Lopez D

PROVIDER: S-EPMC3917285 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Marine natural products with P-glycoprotein inhibitor properties.

Lopez Dioxelis D Martinez-Luis Sergio S

Marine drugs 20140122 1

P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that mo ...[more]

PMID: 24451193

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