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Pharmacogenetics in chronic heart failure: new developments and current challenges.

ABSTRACT: The individual patient responses to chronic heart failure (HF) pharmacotherapies are highly variable. This variability cannot be entirely explained by clinical characteristics, and genetic variation may play a role. Therefore, this review will summarize the background pharmacogenetic literature for major HF pharmacotherapy classes (ie, ?-blockers, angiotensin-converting enzyme inhibitors, digoxin, and loop diuretics), evaluate recent advances in the HF pharmacogenetic literature in the context of previous findings, and discuss the challenges and conclusions for HF pharmacogenetic data and its clinical application.

SUBMITTER: Talameh JA

PROVIDER: S-EPMC3917307 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Pharmacogenetics in chronic heart failure: new developments and current challenges.

Talameh Jasmine A JA Lanfear David E DE

Current heart failure reports 20120301 1

The individual patient responses to chronic heart failure (HF) pharmacotherapies are highly variable. This variability cannot be entirely explained by clinical characteristics, and genetic variation may play a role. Therefore, this review will summarize the background pharmacogenetic literature for major HF pharmacotherapy classes (ie, β-blockers, angiotensin-converting enzyme inhibitors, digoxin, and loop diuretics), evaluate recent advances in the HF pharmacogenetic literature in the context o ...[more]

PMID: 22135185

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