Ontology highlight
ABSTRACT:
SUBMITTER: Bartesaghi A
PROVIDER: S-EPMC3917492 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Bartesaghi Alberto A Merk Alan A Borgnia Mario J MJ Milne Jacqueline L S JL Subramaniam Sriram S
Nature structural & molecular biology 20131023 12
The activation of trimeric HIV-1 envelope glycoprotein (Env) by its binding to the cell-surface receptor CD4 and co-receptors (CCR5 or CXCR4) represents the first of a series of events that lead to fusion between viral and target-cell membranes. Here, we present the cryo-EM structure, at subnanometer resolution (~6 Å at 0.143 FSC), of the 'closed', prefusion state of trimeric HIV-1 Env complexed to the broadly neutralizing antibody VRC03. We show that three gp41 helices at the core of the trimer ...[more]