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Association of a polymorphism of BTN2A1 with chronic kidney disease in community-dwelling individuals.

ABSTRACT: Results of recent studies have shown that the C?T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction. The aim of the current study was to examine the association of rs6929846 of BTN2A1 with chronic kidney disease (CKD) in community-dwelling individuals. Study subjects comprised 1,709 community-dwelling individuals, including 435 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2] and 1,274 controls (eGFR?90 ml/min per 1.73 m2) who were recruited to a population-based cohort study. Genotype distributions (P=0.0010) and allele frequencies (P=0.0002) of rs6929846 were significantly associated with CKD. Multivariate logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (P=0.0002; odds ratio, 2.02; dominant model) associated with CKD, with the minor T allele representing a risk for this condition. The serum concentrations of creatinine were significantly (P=0.0107) higher for all the individuals, whereas eGFR was significantly (P=0.0468) lower for individuals in the combined group of CT and TT genotypes compared to those with the CC genotype. BTN2A1 may therefore be a susceptibility gene for CKD.

SUBMITTER: Oguri M

PROVIDER: S-EPMC3917595 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Association of a polymorphism of BTN2A1 with chronic kidney disease in community-dwelling individuals.

Oguri Mitsutoshi M Fujimaki Tetsuo T Horibe Hideki H Kato Kimihiko K Ichihara Sahoko S Yamada Yoshiji Y

Biomedical reports 20130925 6

Results of recent studies have shown that the C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction. The aim of the current study was to examine the association of rs6929846 of BTN2A1 with chronic kidney disease (CKD) in community-dwelling individuals. Study subjects comprised 1,709 community-dwelling individuals, including 435 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ...[more]

PMID: 24649044

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Project description:ImportanceCognitive deficits constitute core features of schizophrenia, but the trajectories of cognitive difficulties in chronic untreated schizophrenia remain unclear.ObjectiveTo assess the association of neuropsychological deficits with duration of untreated psychosis in individuals with chronic untreated schizophrenia.Design, setting, and participantsCommunity-dwelling individuals with chronic untreated schizophrenia (untreated patient group) and individuals without mental illness (control group) were recruited from predominantly rural communities in Ningxia, China between June 20, 2016, and August 6, 2019, and administered the Structured Clinical Interview for DSM-IV, the Mini-Mental State Examination, an 8-test version of the MATRICS Consensus Cognition Battery adapted for use in individuals with low levels of education, and a measure of social cognition.Main outcomes and measuresComparison of cognitive test scores between the two groups and association of cognitive test scores with duration of untreated schizophrenia.ResultsThe patient group included 197 individuals with chronic untreated schizophrenia (101 men [51.3%]; mean [SD] age, 52.1 [11.8] years; median [interquartile range] years of schooling, 3 [0-6] years; median [interquartile range] years of untreated psychosis, 22.9 [14.9-32.8] years). The control group included 220 individuals (118 men [53.6%]; mean [SD] age, 52.1 [11.2] years; median [interquartile range] years of schooling, 4 [0-6] years). The untreated patient group performed significantly worse than the control group on all cognitive measures (adjusted partial Spearman correlation coefficient [Spearman ρ] ranged from -0.35 for the revised Chinese version of the Reading the Mind in the Eyes Test to -0.60 for the Brief Visuospatial Memory Test-Revised; P < .001 for all comparisons). Longer durations of untreated psychosis were associated with lower performance in 3 MATRICS Consensus Cognition Battery measures assessing different aspects of executive functioning (Brief Visuospatial Memory Test-Revised [ρ = -0.20; P = .04]; Brief Assessment of Cognition in Schizophrenia, Symbol Coding subtest [ρ = -0.35; P < .001]; and Neuropsychological Assessment Battery, Mazes subtest [ρ = -0.24; P = .01]). The median duration of untreated psychosis (22.9 years) was associated with estimated score reductions in the 3 measures of 34% (95% CI, 10%-52%), 43% (95% CI, 28%-55%), and 57% (95% CI, 31%-73%), respectively.Conclusions and relevanceThe findings of this study suggest that long-term untreated schizophrenia was associated with decreases in selective cognitive abilities; both neurodegenerative pathology and neurodevelopmental dysfunction may be factors in cognition in persistent psychosis. Expanding research to include cohorts of patients from underserved rural communities in low- and middle-income countries may provide new insights about the etiological factors, disease course, and management of schizophrenia.

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Association of a polymorphism of BTN2A1 with chronic kidney disease in community-dwelling individuals.

Publications

Association of a polymorphism of <i>BTN2A1</i> with chronic kidney disease in community-dwelling individuals.

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