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Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica.

ABSTRACT: Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors.

SUBMITTER: Stout EP

PROVIDER: S-EPMC3917718 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica.

Stout E Paige EP Wang Yong-Gang YG Romo Daniel D Molinski Tadeusz F TF

Angewandte Chemie (International ed. in English) 20120404 20

Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors. ...[more]

PMID: 22473581

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