Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers.
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ABSTRACT:
SUBMITTER: Sasaki H
PROVIDER: S-EPMC3917728 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers.
Sasaki Hidefumi H Suzuki Ayumi A Shitara Masayuki M Hikosaka Yu Y Okuda Katsuhiro K Moriyama Satoru S Yano Motoki M Fujii Yoshitaka Y
Biomedical reports 20130319 3
The metabolism of xenobiotics plays a fundamental role in smoking-related lung function loss and the development of pulmonary disease. An NRF2-dependent response is a key protective mechanism against oxidative stress. In the present study, we evaluated the effect of single nucleotide polymorphisms in NRF2 genes on the level of forced expiratory volume in one second (FEV1) in lung cancers of smokers. We genotyped the status of NRF2 gene polymorphisms in 209 surgically treated lung cancer cases of ...[more]
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