Dataset Information
Vitamin D levels vary during antiviral treatment but are unable to predict treatment outcome in HCV genotype 1 infected patients.
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ABSTRACT: Background
Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed.Methods
In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-? and ribavirin for 24-72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome.Results
Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P?=?0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR?=?1.028, CI?=?1.002-1.056, P?=?0.035), cholesterol (OR?=?0.983, CI?=?0.975-0.991, P<0.001), ferritin (OR?=?1.002, CI?=?1.000-1.004, P?=?0.033), gGT (OR?=?1.467, CI?=?1.073-2.006, P?=?0.016) and IL28B-genotype (OR?=?2.442, CI?=?1.271-4.695, P?=?0.007) constituted the strongest predictors of treatment response.Conclusions
While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients.
SUBMITTER: Grammatikos G
PROVIDER: S-EPMC3917831 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Vitamin D levels vary during antiviral treatment but are unable to predict treatment outcome in HCV genotype 1 infected patients.
PloS one 20140207 2
<h4>Background</h4>Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has ...[more]