TRPV3 channels mediate strontium-induced mouse-egg activation.
Ontology highlight
ABSTRACT:
SUBMITTER: Carvacho I
PROVIDER: S-EPMC3918412 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
TRPV3 channels mediate strontium-induced mouse-egg activation.
Carvacho Ingrid I Lee Hoi Chang HC Fissore Rafael A RA Clapham David E DE
Cell reports 20131205 5
In mammals, calcium influx is required for oocyte maturation and egg activation. The molecular identities of the calcium-permeant channels that underlie the initiation of embryonic development are not established. Here, we describe a transient receptor potential (TRP) ion channel current activated by TRP agonists that is absent in TrpV3(-/-) eggs. TRPV3 current is differentially expressed during oocyte maturation, reaching a peak of maximum density and activity at metaphase of meiosis II (MII), ...[more]
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