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Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles.

ABSTRACT: DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

SUBMITTER: Jiang X 

PROVIDER: S-EPMC3918481 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles.

Jiang Xuan X   Qu Wei W   Pan Deng D   Ren Yong Y   Williford John-Michael JM   Cui Honggang H   Luijten Erik E   Mao Hai-Quan HQ  

Advanced materials (Deerfield Beach, Fla.) 20121011 2

DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism. ...[more]

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