Ontology highlight
ABSTRACT:
SUBMITTER: Cheng I
PROVIDER: S-EPMC3918490 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Cheng Iona I Kocarnik Jonathan M JM Dumitrescu Logan L Lindor Noralane M NM Chang-Claude Jenny J Avery Christy L CL Caberto Christian P CP Love Shelly-Ann SA Slattery Martha L ML Chan Andrew T AT Baron John A JA Hindorff Lucia A LA Park Sungshim Lani SL Schumacher Fredrick R FR Hoffmeister Michael M Kraft Peter P Butler Anne M AM Duggan David J DJ Hou Lifang L Carlson Chris S CS Monroe Kristine R KR Lin Yi Y Carty Cara L CL Mann Sue S Ma Jing J Giovannucci Edward L EL Fuchs Charles S CS Newcomb Polly A PA Jenkins Mark A MA Hopper John L JL Haile Robert W RW Conti David V DV Campbell Peter T PT Potter John D JD Caan Bette J BJ Schoen Robert E RE Hayes Richard B RB Chanock Stephen J SJ Berndt Sonja I SI Küry Sebastien S Bézieau Stephane S Ambite Jose Luis JL Kumaraguruparan Gowri G Richardson Danielle M DM Goodloe Robert J RJ Dilks Holli H HH Baker Paxton P Zanke Brent W BW Lemire Mathieu M Gallinger Steven S Hsu Li L Jiao Shuo S Harrison Tabitha A TA Seminara Daniela D Haiman Christopher A CA Kooperberg Charles C Wilkens Lynne R LR Hutter Carolyn M CM White Emily E Crawford Dana C DC Heiss Gerardo G Hudson Thomas J TJ Brenner Hermann H Bush William S WS Casey Graham G Le Marchand Loïc L Peters Ulrike U
Gut 20130809 5
<h4>Objective</h4>Genome-wide association studies have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesised that SNPs previously associated with other cancers may additionally be associated with colorectal cancer. In a large-scale study, we examined 171 SNPs previ ...[more]