Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.
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ABSTRACT:
SUBMITTER: Ventham NT
PROVIDER: S-EPMC3919211 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.
Ventham Nicholas T NT Kennedy Nicholas A NA Nimmo Elaine R ER Satsangi Jack J
Gastroenterology 20130608 2
In the past decade, there have been fundamental advances in our understanding of genetic factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis. The latest international collaborative studies have brought the number of IBD susceptibility gene loci to 163. However, genetic factors account for only a portion of overall disease variance, indicating a need to better explore gene-environment interactions in the development of IBD. Epigenetic factors c ...[more]
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