Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt J
PROVIDER: S-EPMC3919508 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Schmidt Joshua J Ehasz Clayton C Epperson Michael M Klas Kimberly K Wyatt Justin J Hennig Mirko M Forconi Marcello M
Organic & biomolecular chemistry 20131105 48
Recent work on a computationally-designed retroaldolase RA-61 suggested that most of the rate-acceleration brought about by this enzyme was due to non-specific interactions with the aromatic substrate. To provide a benchmark for the role of non-specific interactions in this system, we measured the second-order rate constant for the amine-catalysed retro-aldol reaction of methodol in the presence of non-specific hydrophobic pockets such as micelles. We found that a simple micellar system, that co ...[more]