Ontology highlight
ABSTRACT:
SUBMITTER: Raman R
PROVIDER: S-EPMC3919554 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Raman R R Kumar R S RS Hinge A A Kumar S S Nayak R R Xu J J Szczur K K Cancelas J A JA Filippi M-D MD
Leukemia 20130408 11
Hematopoiesis is regulated by components of the microenvironment, so-called niche. Here, we show that p190-B GTPase-activating protein (p190-B) deletion in mice causes hematopoietic failure during ontogeny, in p190-B(-/-) fetal liver and bones, and in p190-B(+/-) adult bones and spleen. These defects are non-cell autonomous, as we previously showed that transplantation of p190-B(-/-) hematopoietic cells into wild-type (WT) hosts leads to normal hematopoiesis. Coculture of mesenchymal stem (MSC)/ ...[more]