Ontology highlight
ABSTRACT:
SUBMITTER: Zhao B
PROVIDER: S-EPMC3919571 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Nucleic acids research 20131108 3
DNA methylation has been proven to be a critical epigenetic mark important for various cellular processes. Here, we report that redox-active quinones, a ubiquitous class of chemicals found in natural products, cancer therapeutics and environment, stimulate the conversion of 5 mC to 5 hmC in vivo, and increase 5 hmC in 5751 genes in cells. 5 hmC increase is associated with significantly altered gene expression of 3414 genes. Interestingly, in quinone-treated cells, labile iron-sensitive protein f ...[more]