Ontology highlight
ABSTRACT:
SUBMITTER: Spitz MR
PROVIDER: S-EPMC3919666 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Spitz Margaret R MR Gorlov Ivan P IP Amos Christopher I CI Dong Qiong Q Chen Wei W Etzel Carol J CJ Gorlova Olga Y OY Chang David W DW Pu Xia X Zhang Di D Wang Liang L Cunningham Julie M JM Yang Ping P Wu Xifeng X
Cancer discovery 20110825 5
Lung cancer in lifetime never smokers is distinct from that in smokers, but the role of separate or overlapping carcinogenic pathways has not been explored. We therefore evaluated a comprehensive panel of 11,737 single-nucleotide polymorphisms (SNP) in inflammatory-pathway genes in a discovery phase (451 lung cancer cases, 508 controls from Texas). SNPs that were significant were evaluated in a second external population (303 cases, 311 controls from the Mayo Clinic). An intronic SNP in the ACVR ...[more]