Ontology highlight
ABSTRACT:
SUBMITTER: Novoyatleva T
PROVIDER: S-EPMC3920183 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Novoyatleva Tatyana T Sajjad Amna A Engel Felix B FB
Frontiers in immunology 20140211
Tumor necrosis factor (TNF) has been firmly established as a pathogenic factor in heart failure, a significant socio-economic burden. In this review, we will explore the role of other members of the TNF/TNF receptor superfamily (TNFSF/TNFRSF) in cardiovascular diseases (CVDs) focusing on TWEAK and its receptor Fn14, new players in myocardial remodeling and heart failure. The TWEAK/Fn14 pathway controls a variety of cellular activities such as proliferation, differentiation, and apoptosis and has ...[more]