Human norovirus detection and production, quantification, and storage of virus-like particles.
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ABSTRACT:
SUBMITTER: Debbink K
PROVIDER: S-EPMC3920292 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Human norovirus detection and production, quantification, and storage of virus-like particles.
Debbink Kari K Costantini Veronica V Swanstrom Jesica J Agnihothram Sudhakar S Vinjé Jan J Baric Ralph R Lindesmith Lisa L
Current protocols in microbiology 20131105
Human noroviruses constitute a significant worldwide disease burden. Each year, noroviruses cause over 267 million infections, deaths in over 200,000 children under the age of five, and over 50% of U.S. food-borne illness. Due to the absence of a tissue culture model or small animal model to study human norovirus, virus-like particles (VLPs) and ELISA-based biological assays have been used to answer questions about norovirus evolution and immunity as well to provide a potential vaccine platform. ...[more]
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