Ontology highlight
ABSTRACT:
SUBMITTER: Riese SB
PROVIDER: S-EPMC3921101 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Riese Sebastian B SB Kuehne Christian C Tedder Thomas F TF Hallmann Rupert R Hohenester Erhard E Buscher Konrad K
Journal of immunology (Baltimore, Md. : 1950) 20140115 4
Selectins are a family of adhesion receptors designed for efficient leukocyte tethering to the endothelium under shear. As a key property to resist premature bond disruption, selectin adhesiveness is enhanced by tensile forces that promote the conversion of a bent into an extended conformation of the N-terminal lectin and epidermal growth factor-like domains. Conformation-specific Abs have been invaluable in deciphering the activation mechanism of integrins, but similar reagents are not availabl ...[more]